Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis
نویسندگان
چکیده
منابع مشابه
Immune cell distribution and immunoglobulin levels change following sciatic nerve injury in a rat model
Objective(s): To investigate the systemic and local immune status of two surgical rat models of sciatic nerve injury, a crushed sciatic nerve, and a sciatic nerve transection Materials and Methods:Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham-operation (control group), sciatic nerve crush, and sciatic nerve transaction. Sciatic nerve surgery was perfor...
متن کاملChanges in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection.
Peripheral nerve transection has been implicated to cause a production of neuronal nitric oxide synthase (nNOS), which may influence a range of post-axotomy processes necessary for neuronal survival and nerve regeneration. Carboxy-terminal post synaptic density protein/Drosophila disc large tumor suppressor/zonula occuldens-1 protein (PDZ) ligand of neuronal nitric oxide synthase (CAPON), as an...
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BACKGROUND Peripheral nerve repair is often complicated by fibroblastic scar formation, nerve dysfunction, and traumatic neuroma formation. Use of silicone may improve outcomes of these repairs. In this study, we tried to evaluate effectiveness of silicone gel on rats’ sciatic nerve repair, axon regeneration and scar formation around and in the nervous tissues. METHODS This experimental stud...
متن کاملLysosomes in the Rat Sciatic Nerve following Crush
Peripheral nerves undergoing degeneration are favorable material for studying the types, origins, and functions of lysosomes. The following lysosomes are described: (a) Autophagic vacuoles in altered Schwann cells. Within these vacuoles the myelin and much of the axoplasm which it encloses in the normal nerve are degraded (Wallerian degeneration). The delimiting membranes of the vacuoles appare...
متن کاملNeurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve
BACKGROUND Cutaneous peripheral neuropathies have been associated with changes of the sensory fiber innervation in the dermis and epidermis. These changes are mediated in part by the increase in local expression of trophic factors. Increase in target tissue nerve growth factor has been implicated in the promotion of peptidergic afferent and sympathetic efferent sprouting following nerve injury....
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ژورنال
عنوان ژورنال: International Journal of Morphology
سال: 2015
ISSN: 0717-9502
DOI: 10.4067/s0717-95022015000200056